Anesthesia management in obese patients is often challenging due to associated comorbidities like hypertension, dyslipidemia, ischemic heart disease, diabetes mellitus, osteoarthritis, liver disease, asthma, obstructive sleep apnea (OSA), and obesity-hypoventilation syndrome. Obese patients may experience perioperative hypoxemia due to reduced functional residual capacity (FRC) and increased oxygen demand, emphasizing the importance of appropriate oxygenation in improving patient safety. High-flow nasal oxygenation (HFNO) is a relatively newer technique of oxygenation with rapidly increasing applications. It delivers high fraction of inspired oxygen (FiO₂) compared to conventional oxygen delivery systems, with a flow rate of up to 70 L/minute, which matches or even exceeds patients’ peak inspiratory flow rate. A 66-year-old female, weighing 160 kg, 150 cm in height, body mass index (BMI) 71.1 kg/m², morbidly obese, came with complaints of postmenopausal bleeding and was posted for hysteroscopy with dilatation and curettage. We describe the management of a morbidly obese patient for dilation and curettage (D&C) hysteroscopy in a nonbariatric setup to highlight the effective usage of HFNO and various other challenges faced.