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VOLUME 4 , ISSUE 2 ( July-December, 2019 ) > List of Articles


Ventilator-associated Pneumonia

Keywords : Aspiration, Intubation, Mechanical ventilation, Ventilator-associated pneumonia

Citation Information : Ventilator-associated Pneumonia. Res Inno Anesth 2019; 4 (2):55-59.

DOI: 10.5005/jp-journals-10049-0075

License: CC BY-NC 4.0

Published Online: 01-08-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Ventilator-associated pneumonia (VAP) is the most frequent intensivecare unit (ICU)-acquired infection for patients on mechanical ventilators. There are no goal standards for VAP diagnosis and this makes it the leading cause of death in critically ill patients. The prediction of its outcome is important in the decision-making process and management. This article reviews the various aspects of VAP such as definition, risk factors, etiological agents, diagnosis, treatment, and prevention with emphasis on the recent advances.

  1. American Thoracic Society. Infectious diseases society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005;171(4):388. DOI: 10.1164/rccm.200405-644ST.
  2. Gunasekera P, Gratrix A. Ventilator-associated pneumonia. BJA Educat 2016;16(6):198–202. DOI: 10.1093/bjaed/mkv046.
  3. National Healthcare Safety Network (NHSN) July 2013 CDC/NHSN Protocol Clarifications 2013.
  5. Kalanuria AA, Zai W, Mirski M. Ventilator-associated pneumonia in the ICU. Crit Care 2014;18(2):208. DOI:
  6. Joseph NM, Sistla S, Dutta TK, et al. Ventilator-associated pneumonia: A review. Eur J Intern Med 2010;21(5):360–368. DOI: 10.1016/j.ejim.2010.07.006.
  7. Zolfaghari PS, Wyncoll DL. The tracheal tube: gateway to ventilator-associated pneumonia. Crit Care 2011;15:310-317. DOI: 10.1186/cc10352.
  8. Koenig SM, Truwit JD. Ventilator-associated pneumonia: diagnosis, treatment, and prevention. Clin Microbiol Rev 2006;19(4):637–657. DOI: 10.1128/CMR.00051-05.
  9. Berton DC, Kalil AC, Cavalcanti M, et al. Quantitative versus qualitative cultures of respiratory secretions for clinical outcomes in patients with ventilator-associated pneumonia. Cochrane Database Syst Rev 2012. CD006482. DOI: 10.1002/14651858.CD006482.pub3.
  10. Silvestri L, Van Saene HKF, Casarin A, et al. Impact of selective decontamination of the digestive tract on carriage and infection due to gram-negative and gram-positive bacteria: a systematic review of randomised controlled trials. Anaesth Intensive Care 2008;36(3):324. DOI: 10.1177/0310057X0803600304.
  11. Meduri GU. Diagnosis and differential diagnosis of ventilator-associated pneumonia. Clin Chest Med 1995;16(1):61.
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